Redox Chemistry and Biology of Thiols

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Due to their chemical and biological versatility, thiol processes play novel roles as signaling regulators of metabolism, post-translational modifications, catalytic functions across bodily systems, protein folding and trafficking, and protein switch modulation. Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods, and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate exciting new research directions, new applications of thiol studies, and clinical translation. Here, more than thirty international experts discuss cysteine reactivity and residues, thiol oxidizing species, thiol modifications, thioredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfides, thiol-based redox biosensors, plant thiols, blood thiols, sugar thiols, and thiol associated recombinant expression, as well as methods and bioinformatics tools for study of thiols, including proteomics and mass spectrometry.