Systems Chemical Biology

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This book will provide a descriptive outline of both the fundamental and the applied aspects of systems chemical biology approaches, focused primarily on the drug discovery context. It will cover a broad range of aspects related to prediction of phenotypic outcome to interfering with key pathways, as well as the design of small molecule modulators aimed at causing a desired phenotype (or to reverse a given diseased phenotype). These relate to both cellular pathways with the goals of understanding and predicting function, and to strategies in multi-drug targeting. This can also be gauged from the rapid growth in the literature in this direction and the creation of new computational/bioinformatics journals. The book will also provide an overview, with easy-to-understand chapters written by pioneers and leaders in the field, as well as advanced material, to inform the readers of the potential caveats which might be involved in a particular task at hand. It also clearly highlight the scope of Systems Chemical Biology and includes case studies where computational network models have provided experimental insight.