The Chemical Biology of Nucleic Acids

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Chemists have played a key role not only in establishing the chemical structure of DNA and RNA but also in helping to understand their structure-function relationship. As chemists have continued over the years to modify the structure and architecture of DNA and RNA for a better insight into their biological functions, Nature has provided new challenges by disclosing some unanticipated novel structures and pathways. These new insights into Nature pose questions where chemistry helps to obtain a deeper understanding. The Chemical Biology of Nucleic Acids focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: * chemical synthesis of modified RNA * expansion of the genetic alphabet in nucleic acids by creating new base pairs * chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides * nucleic-acid-templated chemistry * chemical biology of peptide nucleic acids (PNA) * the interactions of small molecules with DNA and RNA * the architectural modules of folded RNAs * genesis and biological applications of locked nucleic acid (LNA) * small non-coding RNA in bacteria * microRNA-guided gene silencing * nucleic acids based therapies * innate immune recognition of nucleic acid * light-responsive nucleic acids for the spatiotemporal control of biological processes * DNA methylation * frameworks for programming RNA devices * RNA as a catalyst: The Diels-Alderase-Ribozyme * evolving an understanding of RNA function by in vitro approaches * the chemical biology of aptamers: synthesis and applications * nucleic acids as detection tools * bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.